Marcel Kwiatkowski
Ass.-Prof. Dr. rer. nat.
Institute of Biochemistry
University of Innsbruck
Room no. L.03.013
Center for Chemistry and Biomedicine (CCB) Innrain 80-82, 6020 Innsbruck / Austria
Phone: +43 512 507 - 57527 | Fax: +43 512 507 - 57599
Email: Marcel.Kwiatkowski@uibk.ac.at
Lab for Bioanalytics & Intermediary Metabolism
Our research aims to elucidate molecular mechanisms at the interface of metabolism and protein function in the context of cellular homeostasis, systems biology, epigenetics, cancer and metabolic diseases. The Kwiatkowski lab specialises in mass spectrometry-based cross-omics. This includes state-of-the-art proteomics, metabolomics and metabolic flux analysis. We combine cross-omics with computational modelling, cell and molecular biology to study the regulatory interplay between cellular metabolism and protein modifications. Our technological advances have always been driven by research questions that cannot be addressed with current tools, from basic biochemistry to personalised medicine and applied biotechnology.
We are currently investigating the cellular dynamics of hub metabolites (CoA, acetyl-CoA & acyl-CoAs, SAM, NAD, ATP) and how these molecules control protein modification signatures (acylation, methylation, phosphorylation) and regulatory circuits.
Research Interest
- cellular metabolism
- Protein modifications
- Biomarker research
- Spatially resolved proteo-metabolomics & fluxomics
- LC-MS instrumentation
- Bioanalytical method development
- Computational Cross-OMICs
Research Infrastructure
Our laboratory is equipped with two ultra-high resolution orbitrap mass spectrometers (Eclipse plus ETD, UVPD & 1M resolution, Exploris 480) and a sensitive triple quadrupole mass spectrometer (TQ-XS) for untargeted and targeted proteomics, metabolomics & metabolic flux analysis, and a robotic liquid handling platform (Andrew+) for automated sample processing.
Grant Support
2025 - 2028
Tyrolian Science Fund, F.51214
“Benchmarking of Signal Transduction Signatures in Cancer and Transplantation”
2024 - 2026
Austrian Centre of Industrial Biotechnology, No. 98202
“Peptide Production via Multimers in E. coli and P. pastoris”
2023 - 2025
DOC fellowship to Anna-Sophia Egger, Austrian Academy of Sciences
“Simultaneous Proteo-Metabolome Flux – Deciphering the Regulatory Interplay of Energy Metabolism and Proteome”
2021 - 2023
Tyrolian Science Fund, F.18903
“Yin Yang – the AKT-TSC-mTORC1 Axis”
2020 - 2023
Promotion of Young Talents, University of Innsbruck, 2019-Chem-10
“Functional Dyn-OMICs – Elucidation of aberrant energy metabolism and histone acetylation dynamics in tuberous sclerosis complex disease”
2018 - 2019
Noordelijke Cara Stichting
“Identification of novel molecular mechanisms regulating inflammation in pulmonary macrophages in COPD using differential acetylomics”
2017 - 2019
Marie Skłodowska-Curie Postdoctoral Research Fellowship, No. 713406
“P2B2 – Proteomics Based Pharmacological Biochemistry”
2016
Research Promotion Fund of the Faculty of Medicine Hamburg
“Investigation of the suitability of a pico-second-infrared-laser for the analysis of in-vivo proteomes of tissue samples”
2015 - 2018
Medical Technology Research Centre Hamburg (FMTHH), No. 03FMTHH15
“Development of a quantum mechanical system for the extraction of samples from tissues for molecular diagnostics”
Motivated Bachelor and Master students interested in proteomics, metabolomics and analytical biochemistry are invited to apply for internships or thesis projects. Apply at marcel.kwiatkowski@uibk.ac.at.