Phänotypisierung von Talaromyces wortmannii und Beauveria brongniartii hinsichtlich Morphologie, Wachstum und chemischer Diversität mit Hilfe von kombiniertem OSMAC-approach und Co-Kultivierung

 

Student/in: markus Andreas Meitinger, BSc
Termin: 23.05.2024, 10:00 Uhr
Ort: Seminarraum Biologie (Foyer)

1. Prüfer/in: Mag. Dr. Pamela Vrabl
2. Prüfer/in: Mag. Dr. Hermann Strasser
Vorsitzende/r: Priv.-Doz. Dr. Bianka Siewert

 

Interessierte Kolleginnen und Kollegen sind herzlich willkommen!

 

Abstract

With the rising need for novel antibiotics, antifungals and biological pest control in agriculture, the search for compounds which are usable in the context of human health and agriculture is becoming a important challenge for modern microbiology. Because of the developments in genome sequencing a lot of silent gene clusters have been found in filamentous fungi which pose great potential for novel chemical diversity. This raises the question on how to trigger the expression of such gene clusters which code for the synthesis of natural products (secondary metabolites). 

This study aims to trigger the biosynthesis of natural products through cultivation in dual-culture as well as OSMAC-approach. 

The metabolome of mono and dual-cultures is analyzed and characterized with high performance liquid chromatography and mass spectrometry.