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Research

Research: Topic and projects

Current main research project

Biomolecules/Radiosensitizers

High energetic radiation leads to mutations and damages of biological tissue on a molecular level. It turned out that low energy electrons (Ekin < 15 eV) play an important role in this processes. To get a better understanding about the ongoing processes we also carry out experiments with biomolecules. Another important topic in this research area is related to the stability of radiosensitisers towards the irradiation with low energy electrons. These molecules are used in oncology to improve the sensitivity of tumor cells towards radiation.

Recent Highlight:

Dissociative Electron Attachment Dynamics of a Promising Cancer Drug Indicates Its Radiosensitizing Potential

Farhad Izadi, Thomas Luxford, Barbora Sedmidubská, Eugene Arthur-Baidoo, Jaroslav Kočišek, Milan Ončák, Stephan Denifl, S. 

Angewandte Chemie International Edition 63/41, No. e202407469, 2024

DOI: https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202407469

Current projects and third-party funding

FWF-Projects:

  • Electron interaction with modified nucleobases (I5390)  

 

Former projects:

  • FWF Stand-Alone Project P30332, "Electron attachment to radiosensitiser molecules" (2017-2022)
  • Radiation Biology and Biophysics Doctoral Training Programm Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa/ Portuguese National Funding Agency
  • FWF International Project I1015 "Interatomic coloumbic decay by electron impact" (2012-2017)
  • FWF Stand-Alone Project P24443, “Electron attachment to doped (semi-)liquid clusters” (2012 - 2017)
  • FWF Stand-Alone Project P22665, “Interaction of electrons (ionization/attachment) with nanosized biomolecular systems” (2010 - 2015)
  • Co-PI of FWF Lise Meitner Scholarship, M1445, “Free electron attachment to hydrated biomolecules” (2012-2014)
  • APART fellowship of the Austria Academy of Sciences, “Electron and photon irradiation of molecules relevant for astrobiology: chemical reactions in a cold environment" (2008-2010)
  • Young Scientists grant from the University of Innsbruck, “High resolution electron attachment to molecules embedded in superfluid helium droplets.” (2008)
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