Michael Popp Institute

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Funding

 

Principle Investigator (PI)

2023-2027
FWF (P 36299) "Lipid metabolic mechanisms of EMT/ZEB1-dependent ferroptosis"

2022-2024
Tiroler Wissenschaftsförderung "Communication between the immune microenvironment and ferroptotic cancer cells." 

2022-2023
Phospholipid Research Center (PRC) "Potential of phosphatidyl­cholines with ω3 fatty acids in antileukemic combination therapy"

2022
Austrian Society for Bone and Mineral Research "Silymarin-Mediated Inhibition of Acquired Chemotherapy-Resistance in Osteosarcoma." 

2021-2022
University of Innsbruck  Early Stage Funding 2021 "Link between the regulation of ferroptotic cell death and lipid mediator biosynthesis in macrophages"

2020-2023
FWF (I 4968) “Dual inhibitors inspired from vitamin E”

2020-2024
Bionorica Research “Characterization of natural products, plant extracts and phytopharmaceuticals using molecular biological techniques”

2019-2022
Phospholipid Research Center Heidelberg (PLRC) “Potential of algal phosphatidylcholines containing ω3 fatty acids in the supportive therapy of leukemia and lymphoma”

2018-2021
GRK 1715 (DFG) “Molecular signatures of adaptive stress reactions“; joint project with Prof. Dr. Lorkowski (Nutritional Science, Univ. Jena) „Endogenous metabolites of α-tocopherol as double-edged swords in the regulation of inflammatory stress“

2018-2019
DAAD, exchange program (57389523) „Dual inhibitors of 5-LO and mPGES-1 based on vitamin E analogs (DIVA)”

2018-2021
Joint PhD Program of the Universities Shenzhen and Jena; joint project with Prof. Dr. Baohua Liu (School of Medicine, Univ. Shenzen) „Novel mechanism(s) governing CD36 protein degradation and metabolic homeostasis”

2018
Publication costs (SFB 1278)

2017-2020
DFG (KO 4589/7-1) „5-Lipoxygenase as immunoregulatory target of human endogenous vitamin E metabolites“

2017-2019
Free State of Thuringia – Start-up project of the excellence cluster „Balance of the Microverse“; joint project with PD Dr. Lorena Tuchscherr de Hauschopp (Univ. Hospital Jena) and Prof. Dr. Popp (Univ. Jena) „Role of lipid transfer from host cells to S. aureus during chronic infection and consequences for host immune response“

2017-2018
Phospholipid Research Center Heidelberg (PLRC) “Combination of phosphatidylcholine‐bound polyunsaturated fatty acids with cytoskeleton‐targeting drugs for overcoming Akt‐dependent chemoresistance”

2015-2017
Univ. Jena, funding program “advanced“: “Metabolites of vitamin E as nanomolar inhibitors of 5-lipoxygenase“

2014-2015
Bionorica Global Research Initiative 2013/2014 “Targeting of bioactive lipid networks: a novel pharmacological strategy for anti-inflammatory phytomedicine”

2014-2016
DFG (KO 4589/4-1) “Role of stearoyl-CoA desaturase-1 for the regulation of ER homeostasis by stearoyl-CoA desaturase-1”

2014-2017
Phospholipid Research Center Heidelberg (PLRC) “Inhibition of Akt by polyunsaturated phosphatidylcholine – a novel approach for anti-cancer therapy“

2013-2014
Univ. Jena, funding program „basic“: „Lipids as potential modulators of cancer initiation and progression”

2012-2014
diverse travel fellowships (DAAD; Freundeskreis der pharmazie Jena)

Associated project group leader (as PI)

2018-2021
GRK 1715 (DFG) Support for lipidomics-based projects

2015-2018
GRK 1715 (DFG) “Molecular signatures of adaptive stress reactions“; Ph.D. student: Konstantin Löser; project: “Overcoming persistence mechanisms of anti-tumoral agents by modulating the membrane phospholipid composition”

 

Contribution to coordinated research programs (co-worker/collaborator)

2023-2026
BMBWF (Digital Research Infrastructure) DigiOmics4Austria

2023-2024
COST Action CA19105 Pan-European Network in Lipidomics and EpiLipidomics (EpiLipidNET)

2017-2019
DFG Collaborative Research Center “PolyTarget” (SFB 1278), Project “Exploiting polymer-based delivery systems for anti-inflammatory indirubin-based 6BIGOE derivatives in in vitro and in vivo proof-of-principle studies“

2014-2018
DDFG Collaborative Research Center „ChemBioSys“ (SFB 1127), Project “Chemical mediators in the communication between monocytes/macrophages and cancer cells, and modulation by anti-inflammatory small molecules”

2014-2019
ProExzellence Initiative of Thuringia “RegenerAging“, Project “Influence of aging and gender on macrophage polarization and functional consequences for resolution of inflammation, tissue repair and remodeling“

2014-2017
DFG Research Unit FOR 1406 “Exploiting the Potential of Natural Compounds: Myxobacteria as Source for Leads, Tools, and Therapeutics in Cancer Research“