jose-pittl

Jose Miguel Ramos Pittol, PhD

Junior Group Leader, Post-Doctoral Researcher

Institute of Biochemistry
University of Innsbruck
Room no. L.03.031

Center for Chemistry and Biomedicine (CCB) Innrain 80-82, 6020 Innsbruck / Austria
Phone: +43 512 507 - 57514 | Fax: +43 512 507 - 57599
Email: Jose.Ramos-Pittol@uibk.ac.at

ORCID | Google Scholar

Publications

Enric Mocholi, Laura Russo, Keshav Gopal, Andrew G Ramstead, Sophia M Hochrein, Harmjan R Vos, Geert Geeven, Adeolu O Adegoke, Anna Hoekstra, Robert M van Es, Jose Ramos Pittol, Sebastian Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin C Anderson, Ryan M O’Connell, Martin Vaeth, John Ussher, Boudewijn MT Burgering, Paul J Coffer Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation Cell reports. https://doi.org/10.1016/j.celrep.2023.112583

Ramos-Pittol JM, Fernandes-Freitas I, Milona A, Manchishi SM, Rainbow K, Lam BYH, Tadross JA, Beucher A, Colledge WH, Cebola I, Murphy KG, Miguel-Aliaga I, Yeo GSH, Dhillo WS, Owen BM. Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice. Nat Commun. 2023 May 29;14(1):3076. https://doi.org/10.1038/s41467-023-38618-y

de Wit K, Beuers U, Mukha A, Stigter E, Gulersonmez CM, Ramos Pittol JM, Middendorp S, Takkenberg BR , van Mil SWC#. Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids. Liver International 2022. https://doi.org/10.1111/liv.15491

Stahl Madsen M*, Marjoleine Broekema MF*, Rønn Madsen M, Koppen A, Borgman A, Gräwe C, Thomsen EGK, Westland D, Kranendonk MEG, Groot Koerkamp M, Hamers N, Bonvin AMJJ, Ramos-Pittol JM, Nath Natarajan K, Kersten S, Holstege FCP, Monajemi H, van Mil SWC, Vermeulen M, Kragelund BB, Cassiman D, Mandrup S#, Kalkhoven E#. PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation. Nature Communications 13:2022. https://doi.org/10.1038/s41467-022-34766-9

Moreno S, Ramos Pittol JM, Hartl M, Micura R#. Robust synthesis of 2′-azido modified RNA from 2′-amino precursors by diazotransfer reaction. Organic & Biomolecular Chemistry 39:2022. https://doi.org/10.1039/D2OB01560A

Abdellatif M, Trummer-Herbst V, Heberle AM, Humnig A, Pendl T, Durand S, Cerrato G, Hofer SJ, Islam M, Voglhuber J, Ramos Pittol JM, Kepp O, Hoefler G, Schmidt A, Rainer PP, Scherr D, Von Lewinski D, Bisping E, McMullen JR, Diwan A, Eisenberg T, Madeo F, Thedieck K, Kroemer G, Sedej S#. Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity. Circulation 25:2022 https://doi.org/10.1161/CIRCULATIONAHA.122.059863

Kwiatkowski M, Hotze M, Schumacher J, Asif AR, Ramos Pittol JM, Brenig B, Ramljak S, Zischler H, Herlyn H#. Protein speciation is likely to increase the chance of proteins to be determined in 2‐DE/MS. Electrophoresis 06:2022 https://doi.org/10.1002/elps.202000393

Cadena Sandoval M, Heberle AM, Rehbein U, Barile C, Ramos Pittol JM, Thedieck K. mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases. Front Aging. 2021 Oct 13;2. https://doi.org/10.3389/fragi.2021.761333

Orea-Soufi A, Castillo-Lluva S, Salvador-Tormo N, Martín-Cabrera P, Recuero S, Gabicagogeascoa E, Moreno-Valladares M, Mendiburu-Eliçabe M, Blanco-Gómez A, Ramos-Pittol JM, García-Taboada E, Ocaña A, Cimas FJ, Matheu A, Álvarez-López I, Velasco G, Lorente M. The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer. Cancers (Basel). 2021 Oct 22;13(21):5307. https://doi.org/10.3390/cancers13215307

Ijssennagger N, van Rooijen KS, Magnúsdóttir S, Ramos Pittol JM, Willemsen ECL, de Zoete MR, Baars MJD, Stege PB, Colliva C, Pellicciari R, Youssef SA, de Bruin A, Vercoulen Y, Kuipers F, van Mil SWC. Ablation of liver Fxr results in an increased colonic mucus barrier in mice. JHEP Rep. 2021 Aug 4;3(5):100344. https://doi.org/10.1016/j.jhepr.2021.100344

Prentzell MT *, Rehbein U *, Cadena Sandoval M *, De Meulemeester AS *, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021 Feb 4;184(3):655-674.e27. https://doi.org/10.1016/j.cell.2020.12.024

Ramos Pittol JM, Milona A, Morris I, Willemsen ECL, van derVeen SW, Kalkhoven E, van Mil SWC. FXR isoforms control distinct hepatic metabolic functions via selective DNA binding. Gastroenterology, Nov 2020.
https://doi.org/10.1053/j.gastro.2020.07.036

Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson H, Bijsmans ITGW, Willemsen ECL, Ramos Pittol JM, Miguel-Aliaga I, Bosma P, Burgering B, Williamson C, Vernia S, Dhillo WS, van Mil SWC, Owen BM. Steroidogenic Control of Liver Metabolism Through a Nuclear Receptor-Network. Molecular Metabolism, September 2019. https://doi.org/10.1016/j.molmet.2019.09.007

Passeri D *, Carotti A *, Ramos Pittol JM, Ciaccioli G, Pellicciari G, van Mil SWC, Gioiello A. Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool. MedChemComm, June 2019. https://doi.org/10.1039/C9MD00264B

Ramos Pittol JM, Oruba A, Mittler G, Saccani S, van Essen D. Zbtb7a transduces control of promoter accessibility by diverse transcription factors. PLOS Biology, May 2018. https://doi.org/10.1371/journal.pbio.2004526

Massafra V, Milona A, Vos HR, Ramos RJJ, Gerrits J, Willemsen ECL, Ramos Pittol JM, Ijssennagger N, Houweling M, Prinsen HCMT, Verhoeven-Duif NM, Burgering BMT, van Mil SWC. Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice. Gastroenterology, May 2017. https://doi.org/10.1053/j.gastro.2017.01.014

Bijsmans IT, Milona A, Ijssennagger N, Willemsen EC, Ramos Pittol JM, Jonker JW, Lange K, Hooiveld GJ, van Mil SW. Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology. Biochim Biophys Acta, March 2017. https://doi.org/10.1016/j.bbadis.2016.12.004

Ijssennagger N, Janssen AW, Milona A, Ramos Pittol JM, Hollman DA, Mokry M, Betzel B, Berends FJ, Janssen IM, van Mil SW, Kersten S. Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid. J Hepatology, May 2016. https://doi.org/10.1016/j.jhep.2016.01.016

Olguín-Albuerne M, Ramos-Pittol JM, Coyoy A, Martínez-Briseño CP, Domínguez G, Morán J. Peroxynitrite is Involved in the Apoptotic Death of Cultured Cerebellar Granule Neurons Induced by Staurosporine, but not by Potassium Deprivation. Neurochem Res, February 2016. https://doi.org/10.1007/s11064-015-1805-9

Massafra V, Ijssennagger N, Plantinga M, Milona A, Ramos Pittol JM, Boes M, van Mil SW. Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis. Biochim Biophys Acta, February 2016. https://doi.org/10.1016/j.bbadis.2015.11.001

Bijsmans IT, Guercini C, Ramos Pittol JM, Omta W, Milona A, Lelieveld D, Egan DA, Pellicciari R, Gioiello A, van Mil SW. The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression. Sci Rep, September 2015. https://doi.org/10.1038/srep14086

*Equal contribution, # Corresponding author