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Bianka SIEWERT, Priv.-Doz. Dr. Postdoctoral Researcher
Contact: Institute of Pharmacy/Pharmacognosy University of Innsbruck Center for Chemistry and Biomedicine Innrain 80 - 82/IV Room: L.04.050 6020 Innsbruck / Austria
Heise, N.; Siewert, B.; Ströhl, D.; Hönke, S.; Kazakova, O.; Csuk*, R.; A simple but unusual rearrangement of an oleanane to a taraxerane-28,14β-olide; Steroids, 172, 2021, 108853, https://doi.org/10.1016/j.steroids.2021.108853
Fiala, J.; Schöbel, H.; Vrabl, P.; Dietrich, D.; Hammerle, F.; Altmann, D.J.; Stärz, R.; Peintner, U; Siewert*, B., A new High-Throughput-Screening-assay for Photoantimicrobials Based on EUCAST Revealed Photoantimicrobials in Cortinariaceae, 2021, Frontiers Microbiology, https://doi.org/10.3389/fmicb.2021.703544
Siewert*, B.; Does the chemistry of fungal pigments demand the existence of photoactivated defense strategies in basidiomycetes?; Photochemical & Photobiological Sciences, 2021, DOI: 10.1007/s43630-021-00034-w
Hammerle, F., Bingger, I., Pannwitz, A., Rutz, A., Wolfender, J.L., Peintner, U., and Siewert*, B.; Targeted Isolation of Photoactive Pigments from Mushrooms Yielded a Highly Potent New Photosensitizer: 7,7’-Biphyscion, 2021, chemRxiv, https://doi.org/10.26434/chemrxiv.13721770.v1
2020
Kramell, A.; Siewert, B.; Wiese, J; Temml, V.; Deigner, H.-P.; Al-Harrasi, A.; Csuk*, R.; The cytotoxicity of brazilin and derivatives might be due to an inhitbiton of the C-SRC-Kinase; Mediterranean Journal of Chemistry, 2020, 10 (8), http://dx.doi.org/10.13171/mjc10802010061536rc
2019
Rainer, B.; Revoltella, S.; Mayr, F.; Moesslacher, J.; Scalfari, V.; Kohl, R.; Waltenberger, B.; Pagitz, K.; Siewert, B.*; Schwaiger*, S.; Stuppner, H.; From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical; European Journal of Medicinal Chemistry, 2019, 184, No. 111738, https://doi.org/10.1016/j.ejmech.2019.111738
Siewert, B.*; Stuppner, H.; The photoactivity of natural products – An overlooked potential of phytomedicines?, Phytomedicine, 2019, 60, No. 152985, https://doi.org/10.1016/j.phymed.2019.152985
Serbian, I.; Siewert, B.; Al-Harrasi, A.; Csuk*, R.; 2-O-(2-Chlorobenzoyl) maslinic acid triggers apoptosis in A2780 human ovarian carcinoma cells, European Journal of Medicinal Chemistry, 2019, 180, S. 457 – 464, https://doi.org/10.1016/j.ejmech.2019.07.049
Siewert, B*.; Vrabl, P.; Hammerle, F.; Bingger, I.; Stuppner, H.; A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes, RSC Advances, 2019, 9/8, S. 4545 – 4552, https://doi.org/10.1039/C8RA10181G
Van Rixel, V.H.S.; Busemann, A.; Wissingh, M.F.; Hopkins, S.L.; Siewert, B.; Van De Griend, C.; Siegler, M.A.; Marzo, T.; Papo, F.; Ferranoni, M.; Gratteri, P.; Bazzicalupi, C.; Messori, L.; Bonnet*, S. ; Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex, Angewandte Chemie International Edition, 2019, 58/28, S. 9378 – 9382, https://doi.org/10.1002/anie.201814532
2018
Siewert, B.; Langerman, M.; Pannewitz, A.; Bonnet*, S.; Synthesis and avidin binding of ruthenium complexes functionalized with a light‐cleavable free biotin moiety; European Journal of Inorganic Chemistry, 2018, 37, 4117-4124, https://doi.org/10.1002/ejic.201800644
2017
Mora, N. L.; Gao, Y.; Gutierrez, M. G.; Peruzzi, J.; Bakker, I.; Peters, R.J.R.W.; Siewert, B.; Bonnet, S.; Kieltyka, R. E.; van Hest, J. C. M.; Malmstadt, N.; Kros*, A., Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes, Soft Matter, 2017, 13 (33), 5580-5588, https://doi.org/10.1039/C7SM00551B
Siewert, B.; Langerman, M.; Hontani, Y.; Kennis, J. T. M.; Van Rixel, V. H. S.; Limburg, B.; Siegler, MA.; Talens Saez, V.; Kieltyka, R. E.; and Bonnet, S.*, Turning on the red phosphorescence of a [Ru(tpy)(bpy)(Cl)]Cl complex by amide substitution: self-aggregation, toxicity, and cellular localization of an emissive ruthenium-based amphiphile, Chemical Communications, 2017, 53, 11126, https://doi.org/10.1039/C7CC02989F
2016
Siewert, B.; Rixel, V.H.S; Rooden, E.J.; Hopkins, S.L.; Moester, J.B.; Ariese, F.; Siegler, M.A.; Bonnet, S.; Chemical Swarming: Depending on Concentration, an Amphiphilic Ruthenium Polypyridyl Complex Induces cell Death via two different Mechanisms"; Chemistry a European Journal, 2016, 22, 10960; https://doi.org/10.1002/chem.201600927
Rixel, V.H.S; Siewert, B.; Hopkins, S.L; Askes, S.; Buseman, A.; Siegler, M.A.; Bonnet, S.; Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two trans coordination sites, Chemical Science, 2016, 7, 4922-4929; https://doi.org/10.1039/C6SC00167J
Hopkins, S. L.; Siewert, B.; Askes, S. H. C.; van Veldhuizen, P.; Zwier, R.; Heger, M.; Bonnet, S.; In vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines, Photochemical & Photobiological Sciences, 2016, 15, 644-653; https://doi.org/10.1039/C5PP00424A
2015
Heller, L.; Sommerwerk, S.; Tzschöckell, F.; Wiemann, J.; Schwarz, S.; Siewert, B.; Al-Harrasi, A.; Csuk, R.; First Occurence of a Furano-glycyrrhetinoate and its cytotoxicity, Archiv der Pharmazie, 2015, 348(12), 889-96, https://doi.org/10.1002/ardp.201500318
Schwarz, S.; Loesche, A.; Lucas, SD; Sommerwerk, S.; Serbian, I; Siewert, B.; Pianowski, E.; Csuk, R.; Converting maslinic acid into an effective inhibitor of acyclcholinesterases, European Journal of Medicinal Chemistry, 2015, 103, 438-445, https://doi.org/10.1016/j.ejmech.2015.09.007
Sommerwerk, S.; Heller, L.; Siewert, B.; Csuk, R.; Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues, Bioorganic & Medicinal Chemistry, 2015, 23 (17), 5595-602, https://doi.org/10.1016/j.bmc.2015.07.031
Heller, L; Schwarz, S; Perl, V.; Köwitsch, A.; Siewert, B.; Cusk, R.; Incorporation of a Michael acceptor enhances the antitumor activity of triterpenoic acids, European Journal of Medicinal Chemistry., 2015, 101, 391-9, https://doi.org/10.1016/j.ejmech.2015.07.004
Schwarz, S.;Siewert, B.; Csuk, R.; Rauter, A.P.; New antitumor 6-chloropurine nucleosides inducing apoptosis and G2/M cell cycle arrest, European Journal of Medicinal Chemistry., 2015, 90, 595-602, https://doi.org/10.1016/j.ejmech.2014.11.019
Siewert, B.; van Rixel, V.H.S; Bahreman, A.; Higgins, S.L.H; Heger, M.; Askes, S., Bonnet, S.; Biological evaluation of light-activatable ruthenium-based anticancer prodrugs; JBIC Journal of Biological Inorganic Chemistry, 2014, 19, S784, https://doi.org/10.1007/s00775-014-1162-1
Siewert, B.; Csuk, R.; Membrane damaging activity of a maslinic acid analog, European Journal of Medicinal Chemistry, 2014, 74, 1-6, https://doi.org/10.1016/j.ejmech.2013.12.031
Schwarz, S.; Siewert, B.; Xavier, N.M.; Jesus, A.R.; Rauter, A.P.; Csuk, R.; A “natural” approach: Synthesis and cytotoxicity of monodesmosidic glycyrrhetinic acid glycosides, European Journal of Medicinal Chemistry, 2014, 72, 78-83, https://doi.org/10.1016/j.ejmech.2013.11.024
Siewert, B.; Wiemann, J.; Köwitsch, A.; The chemical and biological potential of C ring modified triterpenoids, European Journal of Medicinal Chemistry, 2014, 72, 84-101, https://doi.org/10.1016/j.ejmech.2013.11.025
Siewert, B.; Pianowski, E., Obernauer, A., Csuk, R., Towards cytotoxic and selective derivatives of maslinic acid, Bioorganic & Medicinal Chemistry, 2014, 22, 594-615, https://doi.org/10.1016/j.bmc.2013.10.047
2013
Siewert, B.; Pianowski, E.; Csuk, R., Esters and amides of maslinic acid trigger apoptosis in human tumor cells and alter their mode of action with respect to the substitution pattern at C-28, European Journal of Medicinal Chemistry, 2013, 23, 3542-3546, https://doi.org/10.1016/j.ejmech.2013.10.016
Csuk, R.; Albert, S.; Siewert, B.; Synthesis and radical scavenging activities of resveratrol analogs, Archiv der Pharmazie , 2013, 346(7): 504-10, https://doi.org/10.1002/ardp.201300081
Csuk, R;Siewert, B; Wiemann, J., A bioassay-driven discovery of an unexpected selenophene and its cytotoxicity, Bioorganic & Medicinal Chemistry Letters, 2013, 23, 3542-3546, https://doi.org/10.1016/j.bmcl.2013.04.036
Csuk, R.; Nitsche, C.; Sczepek, R.; Schwarz, S.; Siewert, B., Synthesis of Antitumor-Active Betulinic Acid-Derived Hydroxypropargylamines by Copper-Catalyzend Mannich Reactions. Archiv der Pharmazie, 2013, 346, 232-46, https://doi.org/10.1002/ardp.201200428
2012
Csuk, R.; Stark, S.; Nitsche, C.; Barthel, A.; Siewert, B., Alkylidene branched lupane derivatives: Synthesis and antitumor activity, European Journal of Medicinal Chemistry, 2012, 53, 337-345, https://doi.org/10.1016/j.ejmech.2012.04.023
Csuk, R.; Sommerwerk, S.; Wiese, J.; Wagner, C.; Siewert, B.; Kluge, R.; Stroehl, D., Isolation, structure, synthesis and cytotoxicity of an unprecedented flupirtine dimer, Zeitschrift für Naturforschung B - A Journal of Chemical Sciences, 2012, 67, 1297-1304, https://doi.org/10.5560/znb.2012-0258
Csuk, R.;Siewert, B.; Dressel, C.; Schaefer, R., Tormentic acid derivatives: Synthesis and apoptotic activity, European Journal of Medicinal Chemistry, 2012, 56, 237-245, https://doi.org/10.5560/znb.2012-0258
Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Conversions at C-30 of Glycyrrhetinic Acid and Their Impact on Antitumor Activity. Archiv der Pharmazie, 2012, 345, 223-230, https://doi.org/10.1002/ardp.201100046
Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Synthesis and cytotoxic activity of methyl glycyrrhetinate esterified with amino acids. Zeitschrift für Naturforschung B - A Journal of Chemical Sciences, 2012, 67, 731-746, https://doi.org/10.5560/znb.2012-0107
Csuk, R.; Heinold, A.; Siewert, B.; Schwarz, S.; Barthel, A.; Kluge, R.; Ströhl, D., Synthesis and Biological Evaluation of Antitumor-Active Arglabin Derivatives, Archiv der Pharmazie, 2012, 345, 1001, https://doi.org/10.1002/ardp.201100065
Csuk, R.; Albert, S.; Siewert, B.; Schwarz, S., Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents, European Journal of Medicinal Chemistry, 2012, 54, 669-678, https://doi.org/10.1016/j.ejmech.2012.06.015
Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Synthesis and antitumor activity of ring A-modified glycyrrhetinic acid derivatives, Zeitschrift für Naturforschung B - A Journal of Chemical Sciences, 2011, 66, 521-532, https://doi.org/10.1515/znb-2011-0513
Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives, European Journal of Medicinal Chemistry, 2011, 46, 5356-5369, https://doi.org/10.1016/j.ejmech.2011.08.038
Albert, S.; Horbach, R.; Deising, H. B.; Siewert, B.; Csuk, R., Synthesis and antimicrobial activity of (E) stilbene derivatives, Bioorganic & Medicinal Chemistry, 2011, 19, 5155-5166, https://doi.org/10.1016/j.bmc.2011.07.015
Csuk, R.; Barthel, A.; Sczepek, R.; Siewert, B.; Schwarz, S., Synthesis, Encapsulation and Antitumor Activity of New Betulin Derivatives, Archiv der Pharmazie, 2011, 344, 37-49, https://doi.org/10.1002/ardp.201000232
