High energetic radiation leads to mutations and damages of biological tissue on a molecular level. It turned out that low energy electrons (E_kin < 15 eV) play an important role in this processes. To get a better understanding about the ongoing processes we also carry out experiments with biomolecules. Another important topic in this research area is related to the stability of radiosensitisers towards the irradiation with low energy electrons. These molecules are used in oncology to improve the sensitivity of tumor cells towards radiation.

Recent Highlight:

Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage

Lidia Chomicz-Mańka, Anna Czaja, Karina Falkiewicz, Magdalena Zdrowowicz, Karol Biernacki, Sebastian Demkowicz, Farhad Izadi, Eugene Arthur-Baidoo, Stephan Denifl, Zhaoguo Zhu, Burak Ahmet Tufekci, Rachel Harris, Kit H. Bowen, and Janusz Rak

J. Am. Chem. Soc. 2023, 145, 16, 9059–9071

DOI: https://doi.org/10.1021/jacs.3c00591